Siliconization
Siliconisation is a special treatment for vials, bottles and flasks, jars and other glass packaging. This process adds significant value to your final product. Siliconization provides an additional protective layer to fragile molecules and minimizes unwanted interactions between product and glass packaging.
It prevents excessive adhesion of viscous liquids to the inside of the glass packaging and promotes the degree of transparency. The hydrophobic properties of the silicone layer increase the speed and degree of restitution by a significant amount, right down to the last drop. Your advantage: more efficient consumption (cost savings/waste prevention) of medicines and easier administration.
Compatibility tests between the product formulation and the siliconized glass packaging must show the possibility of siliconization. The resistance of the silicone layer depends on the chemical structure as well as the solubility of the pharmaceutical drug.
The siliconization of glass packaging is carried out by spraying the inside of the glass with an aqueous emulsion of polydimethylsiloxane oil, which complies with all pharmaceutical drug specifications. The siliconisation itself takes place in the hot end of the glass manufacturing process. The silicone film is applied to the glass in the relaxation area, the lehr. All glass packages from 5 ml - 1 l, in clear and brown and of type I, II or III can be siliconized. To ensure the quality of the film, the siliconized glass packages must be stored dry and at a moderate temperature.
The quality control of siliconized glass packaging is very accurate and is carried out through samples taken systematically during production.
In the case of Type III glass, a test is carried out after the glass surface has been tested at room temperature. After uniform moistening of the glass packages, a synthetic solution of kaolin and glycerol is used to measure the reaction rate and uniformity of the solution.
Types I and II are subjected to an accelerated aging test (hot method). The glass packages are then filled to 1/5 of their capacity with a synthetic solution of soda ash and citric acid. The glass packages are then sealed and heated for 30 minutes at 121 °C in an autoclave. After cooling, the retraction quality of the solution is measured.
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